In 2002, Revance developed a first in class proprietary technology that has been shown to augment elastin production and improve skin elasticity. Revance was also the first company to show clinical proof and commercialize products in this category.
Elastin is a protein present in the extracellular matrix and is especially abundant in soft tissues that undergo repeated dimensional change, i.e. lungs, blood vessels and skin. The majority of elastin production is limited to a narrow window which peaks in early childhood, declines rapidly, and is nearly repressed by maturity. RTC-101 is the first available technology that has been clinically proven to augment elastin.
In the area of elastin augmentation and dermal remodeling, Revance has developed cosmeceutical compounds that contribute to the restoration of elastin production in the skin. The loss of elastin is not currently addressed by current prescription or cosmeceutical products.
Revance has commercialized the RTC-101 technology as a cosmeceutical product line under the brand name RELASTIN™. The products are currently available for sale in two formulations: Eye Silk (for the under eye area) and Skin Revitalizer (for the face). They are designed to improve the appearance and contour of skin, and reduce fine lines and wrinkles by increasing skin and soft tissue elasticity.